• Jack T Pearson, Magda Chelstowska, Simon P Rowland, Emily Mcilwaine, Eleonora Benhar, Elina Berglund Scherwitzl, Susan Walker, Kristina Gemzell Danielsson, and Raoul Scherwitzl.
• Natural Cycles Nordic AB, Stockholm, Sweden.
• Eur J Contracept Reprod Health Care. 2021 Apr 1; 26 (2): 105-110.

PurposeDigital fertility awareness-based contraception offers an alternative choice for women who do not wish to use hormonal or invasive methods. The aim of this study was to investigate the key demographics of current users of the Natural Cycles app and assess the contraceptive outcomes of women preventing pregnancy in a UK cohort of women.Materials And MethodsThis was a real world observational prospective observational study. The typical-use effectiveness of the method was calculated using both 13-cycle cumulative probability of pregnancy (life table analysis) and Pearl Index for the entire study cohort. Perfect-use PI was calculated using data from cycles where sexual intercourse during the fertile window was marked as protected and no unprotected sex was recorded on fertile days.Results12,247 women were included in the study and contributed an average of 9.9 months of data for a total of 10,066 woman years of exposure. The mean age of the cohort was 30, mean BMI 23.4, the majority were in a stable relationship (83.2%) and had a university degree or higher (83%). The one year typical use, PI was 6.1 (95% CI: 5.6, 6.6) and with perfect-use was 2.0 (95% CI: 1.3, 2.8). 13 cycle pregnancy probability was 7.1%.ConclusionsThis is the first study which describes the use of a digital contraceptive by women in the UK. It describes the demographics of users and how they correlate with the apps effectiveness at preventing pregnancy.

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