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- Pietro Bertini and Fabio Guarracino.
- Cardiothoracic and Vascular Anesthesia and Intensive Care, Department of Anesthesia and Critical Care Medicine, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.
- Curr Opin Crit Care. 2021 Aug 1; 27 (4): 409-415.
Purpose Of ReviewWe describe the pathophysiology of cardiogenic shock (CS), from the main pathways to the inflammatory mechanisms and the proteomic features.Recent FindingsAlthough the classical pathophysiological pathways underlying CS, namely reduced organ perfusion due to inadequate cardiac output and peripheral vasoconstriction, have been well-established for a long time, the role of macro-and micro-hemodynamics in the magnitude of the disease and its prognosis has been investigated extensively only over the last few years. Moreover, to complete the complex picture of CS pathophysiology, the study of cytokine cascade, inflammation, and proteomic analysis has been addressed recently.SummaryUnderstanding the pathophysiology of CS is important to treat it optimally.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
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