• Eur Rev Med Pharmacol Sci · Mar 2017

    Observational Study

    Relationship of serum novel adipokine chemerin levels with body composition, insulin resistance, dyslipidemia and diabesity in Saudi women.

    • S S Habib, A Eshki, B AlTassan, D Fatani, H Helmi, and S AlSaif.
    • Department of Physiology, College of Medicine & King Saud University Hospitals, King Saud University, Riyadh, Kingdom of Saudi Arabia. shahidhabib44@hotmail.com.
    • Eur Rev Med Pharmacol Sci. 2017 Mar 1; 21 (6): 1296-1302.

    ObjectiveChemerin is believed to be a mediator for the adipose tissue inflammation that occurs in obesity. The present study compared chemerin levels between healthy and type 2 diabetic women matched for age and body composition. We also aimed to assess the relationship of serum chemerin levels with body composition, insulin resistance, dyslipidemia, and diabesity.Patients And MethodsThis observational case-control study was conducted at the Departments of Physiology and Medicine, Saud University Riyadh, Saudi Arabia, from September 2013 to April 2014. A total of 100 subjects were recruited, including 51 adult diabetic females, and a control group consisting of 49 healthy females. Finally, 80 subjects were selected as per inclusion criteria. In the finally selected group, 45 of were type 2 diabetics and 35 were healthy subjects matched for age, body mass index (BMI) and body composition with age ranging between 30-65 years. Body composition analysis was estimated using bioelectrical impendence analyzer. Fasting venous blood samples were analyzed for glycemic markers, lipids, and chemerin. Insulin resistance and sensitivity indices were calculated by HOMA-IR and QUICKI using standard formulas.ResultsThe two groups were matched for age, BMI, body fat percentage (BF%), basal metabolic rate (BMR), truncal fat and waist hip ratio (WHR). Serum chemerin levels were higher in diabetics than controls (p=0.001). Systolic blood pressure, weight, fat mass and visceral fat were found to be significantly higher in diabetics when compared to controls. Fasting blood glucose (FBG), glycosylated hemoglobin (HbA1c), low-density lipoprotein (LDL), triglycerides (TG), insulin and HOMA-IR were significantly higher in diabetics compared to controls. While QUICKI and HDL were significantly lower in diabetics compared to controls. Chemerin levels correlated positively with age (r=0.300, p=0.007), waist hip ratio (r=0.250, p=0.026), weight (r=0.270, p=0.016), BMI (r=0.334, p=0.003), BF% (r=0.325, p=0.003), fat mass (r=0.250, p=0.026), visceral fat (r=0.356, p=0.001), truncal fat mass (r=0.245, p=0.030), truncal fat % (r=0.249, p=0.027), serum basal insulin levels (r=0.354, p=0.001) and HOMA IR (0.275, p=0.015), while it correlated inversely with QUICKI (r=-0.283*, p=0.012). In multiple linear regression analysis age (r=0.236, p=0.023), BF% (r=0.265, p=0.014) and basal insulin levels (r=0.265, p=0.014) were independent predictors of chemerin.ConclusionsSerum chemerin levels are elevated in patients with type 2 DM compared to healthy control subjects and are positively correlated with adiposity and Insulin resistance in patients with type 2 DM.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…