• Arch Ital Urol Androl · Sep 2006

    Randomized Controlled Trial Multicenter Study Comparative Study

    Early discharge of hospitalised patients with community-acquired urosepsis when treated with levofloxacin in sequential therapy.

    • Ercole Concia, Federico Marchetti, and LEVT07 Study Group.
    • Department of Infectious Diseases, Policlinico G.B. Rossi, University of Verona, Verona, Italy.
    • Arch Ital Urol Androl. 2006 Sep 1; 78 (3): 112-4.

    ObjectivesTo compare the sequential therapy with levofloxacin with a standard treatment in the management of urosepsis.Materials And MethodsIt was a multicenter, randomized, open label, pilot trial in community acquired urosepsis carried out in 7 hospitals. Levofloxacin administered 500 mg twice a day intravenously and then orally was compared to piperacillin/tazobactam 4 g/0.5 g three times a day, both in combination with amikacin 7.5 mg/Kg twice a day, for a maximum of 14 days. Amikacin could be suspended between day 3-7.ResultsBoth treatments were efficacious and well tolerated in the 47 enrolled patients, even tough the time to clinical stability was shorter in the levofloxacin treated patients (3.9 vs. 4.9 days). In the levofloxacin group the sequential therapy was performed in 19 (82.6%) cases, after 4.8 +/- 1.7 days of parenteral administration (100% in the per-protocol population after 5.1 +/- 1.9 days).ConclusionsThe implementation of the sequential therapy in the levofloxacin group allowed an early hospital discharge in patients with urosepsis and a cost saving in the hospital perspective.

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