• Arch Argent Pediatr · Feb 2021

    Review Case Reports

    Multisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients.

    • Pedro Taffarel, Jorro Barón Facundo F Servicio de Terapia Intensiva del Hospital General de Niños Dr. Pedro de Elizalde (HGNPE), Ciudad Autónoma de Buenos Aires, Argentina., Ana Paula Rodríguez, Jesica Widmer, and Claudia Meregallia.
    • Servicio de Terapia Intensiva del Hospital General de Niños Dr. Pedro de Elizalde (HGNPE), Ciudad Autónoma de Buenos Aires, Argentina.
    • Arch Argent Pediatr. 2021 Feb 1; 119 (1): e26-e35.

    AbstractMultisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. It has a potentially severe course and may occur with cardiovascular failure; mortality is low (2 %). Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.Sociedad Argentina de Pediatría.

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