Archivos argentinos de pediatría
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Arch Argent Pediatr · Feb 2021
Case Reports[SARS-CoV-2 Detection in cerebrospinal fluid in a pediatric patient. Case report].
The SARS-CoV-2 virus, responsible for the COVID-19 pandemic, is an emerging infectious agent. The knowledge of both its infectivity mechanisms and the possible complications and specific treatments is the subject of constant research. ⋯ We describe the clinical case of a 2-month-old patient who consulted for fever without a focus with detection of SARSCoV- 2 by reverse transcription polymerase chain reaction in nasopharyngeal secretions and cerebrospinal fluid. The infant presented good evolution, with resolution of the fever and without compromise or neurological manifestations.
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Arch Argent Pediatr · Feb 2021
Review Case ReportsMultisystem inflammatory syndrome in children related to COVID-19: An update regarding the presentation of two critically ill patients.
Multisystem inflammatory syndrome in children related to COVID-19 is defined as the presence of persistent fever, inflammation, and organ dysfunction, with evidence of past or recent severe acute respiratory syndrome coronavirus 2 infection, and excluding other microbial causes. It overlaps with other inflammatory diseases (Kawasaki disease and toxic shock syndrome) and shares some features with hypercytokinemia conditions (hemophagocytic lymphohistiocytosis and macrophage activation syndrome). It differs from these and severe acute COVID-19 in its clinical presentation and laboratory parameters. ⋯ Here we provide an update on this syndrome and describe the presentation of two clinical cases with cardiovascular dysfunction who required vasoactive support and invasive ventilation. Serum lab tests showed inflammation parameters. Both patients were treated with intravenous immunoglobulin and systemic corticosteroids and had a favorable course.