• Hong Ma, Ting Tan, Jie Wu, Juan Chen, and Xiaohong Zhang.
• General Practice Center, The Sixth People's Hospital of Chengdu, Chengdu, China.
• Int. Arch. Allergy Immunol. 2020 Jan 1; 181 (12): 956-965.

BackgroundPredisposition to hyperthyroidism may be influenced by functional gene polymorphisms in tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), interleukin-4 (IL-4), interleukin-6 (IL-6), and interleukin-10 (IL-10). However, the results of the studies published so far remain discrepant, so we conducted a meta-analysis to more robustly investigate relationships between TNF-α/IL-1/IL-4/IL-6/IL-10 polymorphisms and predisposition to hyperthyroidism.MethodsA comprehensive literature retrieval from PubMed, Embase, Web of Science, WanFang, VIP, and CNKI was endorsed by the authors, and 38 studies were found to be eligible for pooled meta-analyses.ResultsWe found that genotypic frequencies of TNF-α -308 G/A, IL-1A -889 C/T, IL-6 -174 G/C, IL-6 -572 G/C, IL-10 -819 C/T, and IL-10 -1082 A/G polymorphisms among cases were significantly different from those among controls. Moreover, we also found that genotypic frequencies of TNF-α -308 G/A and IL-6 -174 G/C polymorphisms among cases of Caucasian origin were significantly different from those among Caucasian controls, and genotypic frequencies of IL-1A -889 C/T, IL-1B -511 C/T, IL-6 -174 G/C, IL-6 -572 G/C, and IL-10 -1,082 A/G polymorphisms among cases of Asian origin were also significantly different from those among Asian controls.ConclusionsThis meta-analysis suggests that TNF-α -308 G/A, IL-1A -889 C/T, IL-1B -511 C/T, IL-6 -174 G/C, IL-6 -572 G/C, IL-10 -819 C/T, and IL-10 -1,082 A/G polymorphisms may influence predisposition to hyperthyroidism in certain ethnic groups.© 2020 S. Karger AG, Basel.

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