• Bosch Astrid A T M AATM Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The Netherlands; Sp, Evgeni Levin, Marlies A van Houten, Raiza Hasrat, Gino Kalkman, Giske Biesbroek, de Steenhuijsen Piters Wouter A A WAA Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The N, Pieter-Kees C M de Groot, Paula Pernet, Keijser Bart J F BJF Microbiology and Systems Biology Group, TNO, Zeist, The Netherlands; Department of Preventive Dentistry, Academic Center for Dentistry Amsterdam (ACT, Sanders Elisabeth A M EAM Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The Netherlands., and Debby Bogaert.
• Department of Pediatric Immunology and Infectious Diseases, Wilhelmina Children's Hospital/University Medical Center, Utrecht, The Netherlands; Spaarne Gasthuis Academy, Hoofddorp and Haarlem, The Netherlands.
• EBioMedicine. 2016 Jul 1; 9: 336-345.

AbstractBirth by Caesarian section is associated with short- and long-term respiratory morbidity. We hypothesized that mode of delivery affects the development of the respiratory microbiota, thereby altering its capacity to provide colonization resistance and consecutive pathobiont overgrowth and infections. Therefore, we longitudinally studied the impact of mode of delivery on the nasopharyngeal microbiota development from birth until six months of age in a healthy, unselected birth cohort of 102 children (n=761 samples). Here, we show that the respiratory microbiota develops within one day from a variable mixed bacterial community towards a Streptococcus viridans-predominated profile, regardless of mode of delivery. Within the first week, rapid niche differentiation had occurred; initially with in most infants Staphylococcus aureus predominance, followed by differentiation towards Corynebacterium pseudodiphteriticum/propinquum, Dolosigranulum pigrum, Moraxella catarrhalis/nonliquefaciens, Streptococcus pneumoniae, and/or Haemophilus influenzae dominated communities. Infants born by Caesarian section showed a delay in overall development of respiratory microbiota profiles with specifically reduced colonization with health-associated commensals like Corynebacterium and Dolosigranulum, thereby possibly influencing respiratory health later in life. Copyright © 2016 The Authors. Published by Elsevier B.V. All rights reserved.

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