[Research Progress on Role and Mechanism of Elabela in Organ

Zhongguo Yi Xue Ke Xue Yuan Xue Bao · Apr 2021

Review

[Research Progress on Role and Mechanism of Elabela in Organ Fibrosis].

Elabela is a newly discovered peptide in recent years. It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs. Elabela-APJ axis is closely related to organ fibrosis. ⋯ In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors. However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis. This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.

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- Yu Zhang, Pei Ting Luo, Xin Yang Li, and Wen Peng Cui.
- Department of Nephrology,The Second Hospital of Jilin University,Changchun 130041,China.
- Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2021 Apr 28; 43 (2): 278-282.
AbstractElabela is a newly discovered peptide in recent years.It is the endogenous ligand of Apelin receptor(APJ)and plays an important role in embryonic development and adult organs.Elabela-APJ axis is closely related to organ fibrosis.Elabela can protect the functions of heart and kidney by antagonizing renin-angiotensin system and regulating blood pressure.In addition,it can prevent kidney and heart fibrosis by down-regulating the expression of fibrosis and inflammatory factors.However,there is a positive correlation between the level of Elabela and the degree of liver fibrosis,suggesting that Elabela may play a role in promoting liver fibrosis.This review aims to explore the role of Elabela-APJ axis in renal fibrosis,cardiac fibrosis,and liver fibrosis,and to provide a new therapeutic target for organ fibrosis.

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[Research Progress on Role and Mechanism of Elabela in Organ Fibrosis].

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