• J. Neuroimmunol. · Mar 2003

    CD34-positive cells in human umbilical cord blood express nerve growth factor and its specific receptor TrkA.

    • Luisa Bracci-Laudiero, Domenico Celestino, Giuseppe Starace, Alessia Antonelli, Alessandro Lambiase, Annabella Procoli, Carlo Rumi, Marco Lai, Alessandra Picardi, Giovanna Ballatore, Sergio Bonini, and Luigi Aloe.
    • Institute of Neurobiology and Molecular Medicine, CNR, Viale Marx 15/43, 00137 Rome, Italy.
    • J. Neuroimmunol. 2003 Mar 1; 136 (1-2): 130-9.

    AbstractIn this study, we investigated whether hematopoietic stem cells (HSC) and progenitors present in human cord blood can express nerve growth factor (NGF)-specific receptors, TrkA and p75. Our results showed a marked expression of TrkA and NGF in cord blood CD34(+) cells. A gradient of TrkA and NGF expression exists and is highest in cord blood CD34(+) cells, reduced in cord blood mononuclear cells (MNC) and minimal in mononuclear cells isolated from adult peripheral blood. Our findings suggest that NGF may play a role in the differentiation of hematopoietic progenitors and indicate a different requirement for NGF by immune cells, depending on their state of maturity.

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