• J. Neuroimmunol. · Oct 2004

    MHC and non-MHC gene regulation of disease susceptibility and disease course in experimental inflammatory peripheral neuropathy.

    • Katrien L de Graaf, Erik Wallström, Saad Muhallab, Karl-Heinz Wiesmüller, Tomas Olsson, and Robert Weissert.
    • Experimental Neuroimmunology, Department of General Neurology, Centre for Neurology, Hertie Institute for Clinical Brain Research, University of Tübingen, Hoppe-Seyler-Strasse 3, 72076 Tübingen, Germany.
    • J. Neuroimmunol. 2004 Oct 1; 155 (1-2): 73-84.

    AbstractWith a panel of rat strains, we demonstrate a strong impact of the MHC genotype on susceptibility and disease course in experimental autoimmune neuritis induced with peripheral nerve myelin or the P2 peptide 58-81 (KNTEISFKLGQEFEETTADNRKTK). Beside the MHC genotype, non-MHC genes determined disease susceptibility and resistance. The type of disease induced with P2 58-81 was strongly correlated to the strength of the MHC class II isotype interaction with P2 58-81. These findings suggest a link between susceptibility and acute versus chronic disease courses on one hand and the strength of the MHC class II molecule/peptide affinity on the other hand.Copyright 2004 Elsevier B.V.

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