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- Shintaro Sagami, Yoshitaka Ueno, Shinji Tanaka, Kenta Nagai, Ryohei Hayashi, and Kazuaki Chayama.
- Department of Medicine and Molecular Science, Hiroshima University, Japan.
- Intern. Med. 2015 Jan 1; 54 (17): 2167-72.
AbstractA 52-year-old woman with ulcerative colitis was admitted to our hospital for an ulcerative colitis flare-up under salazosulfapyridine therapy. The symptoms improved with high-dose corticosteroids. After prednisolone was tapered to 10 mg, the frequency of diarrhea increased. The diarrhea was accompanied by joint pain and a skin ulcer with abscess formation, which was diagnosed to be pyoderma gangrenosum. The patient was started on adalimumab. A positive response to the adalimumab therapy was observed after 2 weeks, during which time the ulcerative skin lesion healed completely, however, colonic mucosal healing was achieved at 2 months. Therefore, adalimumab appears to be an effective therapeutic option for patients with ulcerative colitis-associated pyoderma gangrenosum.
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