• Dylan P Griswold, Andres Gempeler, Angelos Kolias, Peter J Hutchinson, and Andres M Rubiano.
• From the NIHR Global Health Research Group on Neurotrauma (D.P.G., A.K., P.J.H., A.M.R.), University of Cambridge; Division of Neurosurgery (D.P.G., A.K., P.J.H.), Department of Clinical Neurosciences, Addenbrooke's Hospital, University of Cambridge, Cambridge, United Kingdom; Clinical Research Center (A.G.), Fundación Valle del Lili, Cali; Neuroscience Institute (A.M.R.), INUB-MEDITECH Research Group, El Bosque University, Bogotá; and Neurological Surgery Service (A.M.R.), Vallesalud Clinic, Cali, Colombia.
• J Trauma Acute Care Surg. 2021 Apr 1; 90 (4): e72-e80.

BackgroundHealth care facilities in low- and middle-income countries are inadequately resourced to adhere to current COVID-19 prevention recommendations. Recommendations for surgical emergency trauma care measures need to be adequately informed by available evidence and adapt to particular settings. To inform future recommendations, we set to summarize the effects of different personal protective equipment (PPE) on the risk of COVID-19 infection in health personnel caring for trauma surgery patients.MethodsWe conducted an umbrella review using Living Overview of Evidence platform for COVID-19, which performs regular automated searches in MEDLINE, Embase, Cochrane Central Register of Controlled Trials, and more than 30 other sources. Systematic reviews of experimental and observational studies assessing the efficacy of PPE were included. Indirect evidence from other health care settings was also considered. Risk of bias was assessed with the AMSTAR II tool (Assessing the Methodological Quality of Systematic Reviews, Ottawa, ON, Canada), and the Grading of Recommendations, Assessment, Development, and Evaluation approach for grading the certainty of the evidence is reported (registered in International Prospective Register of Systematic Reviews, CRD42020198267).ResultsEighteen studies that fulfilled the selection criteria were included. There is high certainty that the use of N95 respirators and surgical masks is associated with a reduced risk of COVID-19 when compared with no mask use. In moderate- to high-risk environments, N95 respirators are associated with a further reduction in risk of COVID-19 infection compared with surgical masks. Eye protection also reduces the risk of contagion in this setting. Decontamination of masks and respirators with ultraviolet germicidal irradiation, vaporous hydrogen peroxide, or dry heat is effective and does not affect PPE performance or fit.ConclusionThe use of PPE drastically reduces the risk of COVID-19 compared with no mask use in health care workers. N95 and equivalent respirators provide more protection than surgical masks. Decontamination and reuse appear feasible to overcome PPE shortages and enhance the allocation of limited resources. These effects are applicable to emergency trauma care and should inform future recommendations.Level Of EvidenceReview, level II.Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc.

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