• Pol. Arch. Med. Wewn. · Jul 2021

    Multicenter Study

    Extremely high mortality in COVID-19 hemodialyzed patients in before anty-SARS-CoV-2 vaccination era. The first large database from Poland.

    • Ewelina Puchalska-Reglińska, Alicja Dębska-Ślizień, Bogdan Biedunkiewicz, Piotr Tylicki, Karolina Polewska, Piotr Jagodziński, Bolesław Rutkowski, Ryszard Gellert, and Leszek Tylicki.
    • Dialysis Unit, 7th Navy Hospital in Gdansk, Gdańsk, Poland
    • Pol. Arch. Med. Wewn. 2021 Jul 30; 131 (7-8): 643-648.

    IntroductionPreliminary reports suggested high incidence and mortality rates of SARS‑ CoV 2 infection in patients receiving kidney replacement therapy.ObjectivesWe aimed to describe the incidence and outcomes of COVID‑ 19 in hemodialysis patients.Patients And MethodsWe conducted a retrospective multicenter cohort study on the incidence and mortality of COVID‑ 19 in hemodialysis patients as compared with the general adult population in the period from the beginning of the pandemic until the commencement of the SARS‑ CoV 2 vaccination program. The study population included all patients who were receiving hemodialysis in any of the 14 dialysis units of Pomerania Province, Poland on December 31, 2019 and all individuals who were starting long‑ term hemodialysis between January 1, 2020 and January 31, 2021, amounting to a total of 1567 patients. Data on the general population were obtained from reports of the health authorities.ResultsThe absolute cumulative incidence of SARS‑ CoV 2 infection in hemodialysis patients was 22.4%, and after standardization for age it was 3.98-fold higher compared with the general population (P <0.001). The epidemic trajectory of both groups ran in parallel, but the increase and decline in the number of new cases occurred earlier in hemodialysis patients. The fatality rate of COVID‑ 19 among hemodialysis patients was 30.4%. It was the highest among the oldest patients, reaching 43.81% in individuals aged 75 years or older (P = 0.003). Age‑ standardized fatality and mortality rates in hemodialysis patients were 5.5- and 10.9-fold higher than in controls, respectively (both P <0.001).ConclusionsThe results of this study show the extremely high mortality rate of COVID‑ 19 in hemodialysis patients during the first and second waves of the epidemic in Pomerania Province, before the vaccination era.

      Pubmed     Free full text   Copy Citation     Plaintext  

      Add institutional full text...

    Notes

     
    Knowledge, pearl, summary or comment to share?
    300 characters remaining
    help        
    You can also include formatting, links, images and footnotes in your notes
    • Simple formatting can be added to notes, such as *italics*, _underline_ or **bold**.
    • Superscript can be denoted by <sup>text</sup> and subscript <sub>text</sub>.
    • Numbered or bulleted lists can be created using either numbered lines 1. 2. 3., hyphens - or asterisks *.
    • Links can be included with: [my link to pubmed](http://pubmed.com)
    • Images can be included with: ![alt text](https://bestmedicaljournal.com/study_graph.jpg "Image Title Text")
    • For footnotes use [^1](This is a footnote.) inline.
    • Or use an inline reference [^1] to refer to a longer footnote elseweher in the document [^1]: This is a long footnote..

    hide…