• Quan Yang and Min Li.
• Department of Otolaryngology, Suzhou Hospital of Integrated Traditional Chinese and Western Medicine, China.
• J Coll Physicians Surg Pak. 2021 Jun 1; 31 (6): 699702699-702.

ObjectiveTo compare the therapeutic effects and olfactory function of oral glucocorticoid and intranasal glucocorticoid in patients with chronic rhinosinusitis (CRS) with nasal polyps.Study DesignExperimental study.Place And Duration Of StudySuzhou Hospital of Integrated Traditional Chinese and Western Medicine, from January 2018 to November 2019.MethodologyOne hundred and twenty-two CRS patients with nasal polyps were randomly divided into Group A and Group B with 61 cases in each group. Group A received local application of glucocorticoid (dexamethasone) after nasal endoscopic surgery. Group B received oral glucocorticoid (prednisone) one week before operation and three weeks after operation. Clinical effects of the two groups were compared.ResultsTotal effective rate of Group B was higher than that of Group A (p=0. 023), recurrence rate in Group B was lower than that in Group A (p=0.015). Nasal airway resistance and olfactory function scores of Group B were lower than those of Group A at one month, three months and six months after operation (all p <0.001). There was no difference in the incidence of adverse reactions between the two groups (p=0. 649).ConclusionCompared with intranasal glucocorticoid, oral glucocorticoid can obviously improve the therapeutic effect and olfactory function of patients, and the postoperative recurrence rate is lower. Key Words: Sinusitis, Nasal polyps, Endoscopic sinus surgery, Glucocorticoid.

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