• Anticancer research · Feb 2010

    Case Reports

    Type 2 and clear cell papillary renal cell carcinoma, and tubulocystic carcinoma: a unifying concept.

    • Catriona Brennan, John R Srigley, Clair Whelan, John Cooper, and Brett Delahunt.
    • Pathology Queensland, Princess Alexandra Hospital, Ipswich Road, Woolloongabba, QLD 4102, Australia.
    • Anticancer Res. 2010 Feb 1; 30 (2): 641-4.

    AbstractThe clinical and pathological features of multiple different renal neoplasms arising in a setting of end-stage renal disease in a 72-year-old male are described. The kidney showed features of renal oncocytosis with multiple oncocytomas, hybrid tumours and chromophobe renal carcinoma. In addition, the kidney contained a type 2 papillary renal cell carcinoma, clear cell papillary and cystic renal cell carcinoma, and tubulocystic carcinoma. The occurrence of these three tumours in a setting of end-stage kidney disease is unique and suggests a common pathogenesis. Immunostaining of these tumours further suggests they are derived from similar stem cells which show immunophenotypic features of both the proximal and distal nephron.

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