• Future microbiology · May 2016

    Intranasal treatment with bacteriophage rescues mice from Acinetobacter baumannii-mediated pneumonia.

    • Yong Wang, Zhiqiang Mi, Wenkai Niu, Xiaoping An, Xin Yuan, Huiying Liu, Puyuan Li, Yannan Liu, Yuzhong Feng, Yong Huang, Xianglilan Zhang, Zhiyi Zhang, Hang Fan, Fan Peng, Yigang Tong, and Changqing Bai.
    • Department of Respiratory Medicine, PLA Hospital 307, Beijing 100071, China.
    • Future Microbiol. 2016 May 1; 11: 631-41.

    AimWith the emergence of drug-resistant bacteria, finding alternative agents to treat antibiotic-resistant bacterial infections is imperative.Materials & MethodsA mouse pneumonia model was developed by combining cyclophosphamide pretreatment and Acinetobacter baumannii challenge, and a lytic bacteriophage was evaluated for its therapeutic efficacy in this model by examining the survival rate, bacterial load in the lung and lung pathology.ResultsIntranasal instillation with bacteriophage rescued 100% of mice following lethal challenge with A. baumannii. Phage treatment reduced bacterial load in the lung. Microcomputed tomography indicated a reduction in lung inflammation in mice given phage.ConclusionThis research demonstrates that intranasal application of bacteriophage is viable, and could provide complete protection from pneumonia caused by A. baumannii.

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