• Ann Pharmacother · Dec 2013

    Case Reports

    Varenicline-induced coronary thrombosis.

    • Arzu Kalayci, Aysegul Eren, Gonenc Kocabay, Can Yucel Karabay, Cetin Gecmen, and Cevat Kirma.
    • Cardiology Department, Kartal Kosuyolu Heart and Research Hospital, Istanbul, Turkey.
    • Ann Pharmacother. 2013 Dec 1; 47 (12): 1727-9.

    AbstractVarenicline (Champix, Chantix) has been available for use in smoking cessation since 2006. This drug has been associated with adverse cardiovascular events. Potential mechanisms for this association include modulation of parasymphathetic output from the brainstem to the heart, release of catecholamines and prothrombotic effect. We report the case of a 30-year-old man with no known cardiac disease, who developed thrombotic occlusion of left anterior descending artery and presented with acute coronary syndrome secondary to treatment with varenicline. The Naranjo probability scale indicates that varenicline was the probable cause of the myocardial infarction.

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