• Am J Manag Care · Jun 2021

    Treatment strategies, management of comorbidities, and the role of IL-23 inhibitors in moderate to severe psoriasis.

    • Jerry Bagel.
    • Psoriasis Treatment Center of New Jersey, East Windsor, New Jersey; Icahn School of Medicine at Mount Sinai, New York, New York. Email: Dreamacres1@aol.com.
    • Am J Manag Care. 2021 Jun 1; 27 (10 Suppl): S203-S208.

    AbstractPsoriasis is a complex immune disorder associated with substantial metabolic and psychological comorbidities, posing challenges to treatment. Interleukin (IL)-23 inhibitors, the newest class of biologics for the treatment of moderate to severe psoriasis, are more selective mechanistically than previous biologic classes and may have utility in management of patients with comorbidities, particularly those with metabolic syndrome (MetS). Moreover, recent long-term data suggest that IL-23 inhibitors offer unique advantages in both safety and efficacy. As the relationship between psoriasis and MetS continues to be elucidated, the availability of agents that are safe and effective in patients with and without comorbidities represents an important step in the spectrum of treatment.

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