• Clin Lab · Jan 2012

    Increased fecal calprotectin in preterm infants with necrotizing enterocolitis.

    • Gokhan Aydemir, Ferhat Cekmez, I Asya Tanju, Fuat Emre Canpolat, F Alparslan Genc, Sukran Yildirim, Turan Tunc, and S Umit Sarici.
    • Department ofPediatrics, GATA Medical Faculty, Istanbul, Turkey.
    • Clin Lab. 2012 Jan 1; 58 (7-8): 841-4.

    BackgroundNecrotizing entrocolitis (NEC) remains a potentially fatal disease in premature infants despite the recent advances in neonatal care. It is a disease with a multifactorial etiology leading to the one common final pathway of necrosis and inflammmation of the neonatal intestine.MethodsCalprotectin is a calcium and zinc-binding protein in human neutrophils. Its concentration rises in various organic bowel diseases in adults and is resistant to degradation and has been proposed as a useful, simple, and rapid diagnostic method of inflammatory bowel disease that shows gastrointestinal inflammation in children and adults.ResultsWe found that infants with necrotizing enterocolitis had increased fecal calprotectin concentrations, and there was a correlation between calprotectin concentrations and severity of NEC.ConclusionsWe concluded that fecal calprotectin is a useful marker for diagnosis and severity of NEC in preterm infants.

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