• I-Yuan Joseph Chang, Hakan Ilaslan, Murali Sundaram, Jean Schils, and Naveen Subhas.
• Department of Radiology, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX, 75219, USA. josephchang0@gmail.com.
• Skeletal Radiol. 2018 May 1; 47 (5): 661-669.

ObjectiveTo determine the diagnostic yield of CT-guided percutaneous biopsy of densely sclerotic bone lesions.Materials And MethodsWe retrospectively analyzed CT-guided percutaneous bone biopsies performed at our institution from September 2008 through August 2011 (329 cases) and from September 2012 through August 2015 (324 cases) after adoption of a battery-powered drill system (OnControl). Bone lesions were included in the analysis if they were >70% sclerotic by visual inspection, had a density > 2 times that of adjacent trabecular bone, and had an attenuation of ≥250 HU. Pathological fractures, diskitis-osteomyelitis, and osteoid osteomas were excluded. Eligible cases were characterized by lesion location, maximum lesion diameter, mean density, biopsy needle type and gauge, reported complications, and histological diagnosis. Clinical and imaging follow-up was used to confirm histological diagnosis. Cases in which a benign histological diagnosis could not be confirmed by imaging over a minimum period of 1 year were excluded.ResultsA total of 37 biopsies of sclerotic bone lesions met the inclusion criteria, 17 of which were performed with a power drill needle and 20 of which were performed with a manually driven needle. The mean lesion density was 604.1 HU. The overall diagnostic yield was 78.4%; overall diagnostic accuracy was 94.6%, and the false-negative rate was 5.4%. Diagnostic yield and accuracy were 82.4% and 100% respectively, with a power drill and 75% and 90% respectively, with a manual device. Diagnostic yield for lesions ≥700 HU was 90% (9 out of 10).ConclusionDensely sclerotic bone lesions are amenable to percutaneous needle biopsy.

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