• Ann Fr Anesth Reanim · Oct 2011

    Case Reports

    [Acute valproic acid intoxication: interest of a treatment by extracoporeal elimination combined with L-carnitine].

    • A Alluin, J Jezequel, N Gauthier, J-L Desmaretz, and C Canevet.
    • Service de Réanimation Polyvalente, Centre Hospitalier D'armentières, 112, rue Sadi-Carnot, BP 189, 59421 Armentières Cedex, France. a_alluin@hotmail.com
    • Ann Fr Anesth Reanim. 2011 Oct 1;30(10):752-4.

    AbstractWe present the case of a 24-year-old-female patient, who made an attempt to autolysis with valproic acid, benzodiazepines and neuroleptic. The valproic acid plasma level was very high (1437 μg/mL), confirming it was a severe intoxication. She presents an acute encephalopathy with prolonged status epilepticus, a lactic metabolic acidosis and hematologic disorders such as bicytopenia. Treatment including L-carnintine and continuous veno-venous haemodialysis (CVVHD) was rapidly introduced to prevent the occurrence of cerebral oedema. The evolution was favourable despite the occurrence of a nosocomial ventilation acute lung injury. The patient had motor sequelae of cranial nerves following status epilepticus extended, which disappeared spontaneously after several days.2011 Elsevier Masson SAS. All rights reserved.

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