• Carlo Signorelli, Donatello Gemma, Roberta Grande, Salvatore DE Marco, Rosa Saltarelli, Maria Grazia Morandi, Gian Paolo Spinelli, Federica Zoratto, Isabella Sperduti, Mario Giovanni Chilelli, Anna Ceribelli, and Enzo Maria Ruggeri.
• Medical Oncology Unit, Belcolle Hospital, ASL Viterbo, Viterbo, Italy; carlo.signorelli@asl.vt.it.
• Anticancer Res. 2021 May 1; 41 (5): 2553-2561.

Background/AimRegorafenib (REG) and trifluridine/tipiracil (FTD/TPI) have have been shown to improve overall survival in patients with refractory metastatic colorectal cancer. The aim of our study was to evaluate the efficacy and safety profiles of these agents administered in sequence in real world practice.Patients And MethodsClinical data of patients treated beyond the 2°line with REG or FTD/TPI between January 2016 and August 2020, were retrospectively collected from eight institutes in the Lazio Region.ResultsWe included 49 patients treated with both drug sequences. A total of 28 G3/G4 toxicity events (53.8%) were recorded in the FTD/TPI-to-REG sequence vs. 24 (46.1%) in the reverse sequence. Median overall survival for the patients included in the FTP/TPI-to-REG group was 20 months (95%CI=16.7-23.3) vs. 27 months in the reverse group (95%CI=17.8-36.2). The disease control rate was 45.0% for patients treated with the REG-to-FTD/TPI sequence vs. 24.1% in those treated with the FTD/TPI-to-REG sequence (p=0.18).ConclusionThe sequence REG-to-FTD/TPI and vice versa can extend survival, whereas only REG-to-FTD/TPI stabilizes cancer growth.Copyright © 2021 International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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