• Trond Hagtvedt, Therese Seierstad, Kjersti V Lund, Ayca M Løndalen, Trond V Bogsrud, Hans-Jørgen Smith, Oliver M Geier, Harald Holte, and Trond Mogens Aaløkken.
• Department of Radiology and Nuclear Medicine, Oslo University Hospital, Norway University of Oslo, Norway.
• Acta Radiol. 2015 Feb 1; 56 (2): 152-8.

Background18F fluoro-deoxyglucose (FDG) positron emission tomography / computed tomography (PET/CT) is a well-recognized diagnostic tool used for staging and monitoring of therapy response for lymphomas. During the past decade diffusion-weighted (DW) magnetic resonance imaging (MRI) is increasingly being included in the assessment of tumor response for various cancers.PurposeTo compare the change in maximum standardized uptake value (ΔSUVmax) from FDG PET/CT with the change in apparent diffusion coefficient (ΔADC) from DW MRI after initiation of the first cycle of chemotherapy in patients with Hodgkin's lymphoma (HL) and in patients with diffuse large B-cell lymphoma (DLBCL).Material And MethodsTwenty-seven consecutive patients with histologically proven lymphoma and lymphomatous lymph nodes (LLN) of the neck (19 with HL, 8 with DLBCL) underwent FDG PET/CT and MRI of the neck before and after initiation of the first cycle of chemotherapy. The mean time interval from initiation of chemotherapy to imaging was 19 days and 2 days for FDG PET/CT and MRI, respectively. For each patient ΔSUVmax, ΔADC, and change in volume of the same LLN were compared.ResultsThere was a significant mean decrease of SUVmax by 70%, but no significant change in ADC. There was no significant reduction in LLN volume.ConclusionThere was no significant correlation between ΔSUVmax and ΔADC. Thus, our data do not support that FDG PET/CT can be replaced by early DW MRI for response evaluation in lymphoma patients.© The Foundation Acta Radiologica 2014 Reprints and permissions: sagepub.co.uk/journalsPermissions.nav.

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