• Nobuyuki Matsuhashi, Eiji Sakai, Ken Ohata, Norihisa Ishimura, Junko Fujisaki, Tomoki Shimizu, Katsunori Iijima, Tomoyuki Koike, Takao Endo, Takefumi Kikuchi, Tatsuya Inayoshi, Yuji Amano, Takahisa Furuta, Ken Haruma, and Yoshikazu Kinoshita.
• Department of Gastroenterology, NTT Medical Center Tokyo, Tokyo, Japan.
• J. Gastroenterol. Hepatol. 2017 Feb 1; 32 (2): 409-414.

Background And AimThe incidence of esophageal adenocarcinoma (EAC) in cases with long-segment Barrett's esophagus (BE) has not been investigated in Japan. The aim of this study is to investigate the incidence of EAC in Japanese cases with long-segment BE prospectively.MethodsThis is a multicenter prospective cohort study investigating the incidence rate of EAC in patients with BE with a length of at least 3 cm. Study subjects received index esophagogastroduodenoscopy at the time of enrollment, and they were instructed to undergo yearly follow-up esophagogastroduodenoscopy. Patients in whom EAC was diagnosed in the endoscopic examinations underwent subsequent treatment, and their prognosis was observed.ResultsOf 215 enrolled patients, six (2.8%) were initially diagnosed with EAC at the enrollment. Among the remaining 209 patients, 132 received at least one follow-up esophagogastroduodenoscopy. In this follow-up, three EACs developed in 251 observed patient-years (incidence rate: 1.2% per year). Most of the EACs detected at the initial endoscopic examination (5/6, 83%) were already at advanced stages. Meanwhile, all the three lesions detected in the follow-up esophagogastroduodenoscopies were identified as early cancers and subjected to curative resection.ConclusionsThe incidence rate of EAC in Japanese cases with long-segment BE was calculated to be 1.2% in a year.© 2016 Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd.

30 keywords...

hide…