• Isr Med Assoc J · Jun 2021

    Case Reports

    Tumor-like Lesions in Patients with Granulomatosis with Polyangiitis: A Case Series.

    • Omer Gendelman, Yuval Kuntzman, Ora Shovman, Pnina Langevitz, Avishai M Tsur, Daniel Erez, Yair Levy, and Howard Amital.
    • Department of Medicine B, Sheba Medical Center, Tel Hashomer, Israel.
    • Isr Med Assoc J. 2021 Jun 1; 23 (6): 350-352.

    BackgroundGranulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis. It usually involves the respiratory tract and kidney. Rarely, tumor-resembling inflammatory changes ensue.ObjectivesTo report three unique cases of GPA presenting with tumor-like lesions in various organs.MethodsWe presented three cases of GPA. Case 1 presented with typical upper respiratory symptoms of GPA and a mediastinal mass. Case 2 presented with low back pain, a large retroperitoneal mass, and nodular skin lesions. Case 3 presented with epigastric pain and a paravertebral inflammatory mass.ResultsThe patients were treated successfully with rituximab.ConclusionsClinicians should be aware of this presentation of granulomatosis with polyangiitis, which is known as Tumefaction Wegener's granulomatosis.

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