• Werner Reiche, Volker Schuchardt, Thomas Hagen, Kamil A Il'yasov, Peter Billmann, and Johannes Weber.
• Institut of Radiology, Ortenau Klinikum Lahr-Ettenheim, 77933 Lahr, Germany. reiche.w@t-online.de <reiche.w@t-online.de>
• Clin Neurol Neurosurg. 2010 Apr 1; 112 (3): 218-25.

ObjectiveTo evaluate the contribution of DWI and DTI to the differential diagnosis of cerebral ring enhancing lesions by describing DWI and ADC (apparent diffusion coefficient) findings and measuring the two DTI parameters mean diffusivity (MD) and fractional anisotropy (FA).Materials And MethodsA total of 17 patients presenting with 26 rim enhancing cysts were investigated with DWI and DTI. Parameter maps of the DTI metrics MD and FA were calculated and quantified using regions of interest (ROIs).ResultsFive patients suffered from abscesses with a total of 10 cysts, 9 from glioblastomas with 10 cysts, and 3 from metastases with 6 cysts. All abscess cavities showed hyperintense DWI signal intensity compared to normal appearing white matter (NAWM), low ADC, low MD and high FA. Eight out of 10 glioblastoma cysts and all 6 metastatic cysts revealed hypointensity on DWI, high ADC, high MD and low FA (p<0.0001 compared to abscess group). DWI findings of 2/10 glioblastoma cysts overlapped with those of abscesses showing hyperintensity on DWI, low ADC and low MD and hence mimicked abscesses. FA of these 2 glioblastoma cysts was significantly lower than in abscess cavities (p=0.032).ConclusionThe findings of reduced diffusion compared to NAWM and increased FA within a ring enhancing cyst strongly indicate a cerebral abscess. In contrast, the majority of neoplastic cysts revealed high diffusion and low FA. Reduced diffusion is also found in a very small number of tumour cysts, but in these low FA refers to a non-infectious origin and thus helps distinguishing from infectious abscess.

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