Glial and neuronal markers in cerebrospinal fluid in different

J. Neuroimmunol. · Oct 2016

Observational Study

Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis.

In the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.

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- M Alba Mañé-Martínez, Bob Olsson, Laura Bau, Elisabet Matas, Álvaro Cobo-Calvo, Ulf Andreasson, Kaj Blennow, Lucia Romero-Pinel, Sergio Martínez-Yélamos, and Henrik Zetterberg.
- Joan XXIII University Hospital, Universitat Rovira i Virgili, Tarragona, Spain; Bellvitge University Hospital, Universitat de Barcelona, L'Hospitalet de Llobregat, Barcelona, Spain. Electronic address: unitatem@bellvitgehospital.cat.
- J. Neuroimmunol. 2016 Oct 15; 299: 112-117.
AbstractIn the present study, CSF concentrations of NFL, t-tau, p-tau, GFAP, S-100B, YKL-40, MCP-1, α-sAPP, β-sAPP, and Aβ38, Aβ40, Aβ42 were measured in 324 MS patients to test whether a correlation among the biomarkers exists and whether the profile of CSF biomarkers varies among the different types of MS. The CSF concentrations of NFL were significantly higher in RRMS while CSF concentrations of GFAP were higher in PPMS. CSF concentrations of NFL correlated with YKL-40 in CIS patients while CSF concentrations of GFAP correlated with YKL-40 in RRMS patients.Copyright © 2016 Elsevier B.V. All rights reserved.

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Glial and neuronal markers in cerebrospinal fluid in different types of multiple sclerosis.

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