• Bo Wang, Zhenyu Liu, Jiaojiao Liu, Zhenchao Tang, Hongjun Li, and Jie Tian.
• School of Automation, Harbin University of Science and Technology, Harbin, China.
• J Magn Reson Imaging. 2016 Jun 1; 43 (6): 1474-83.

PurposeTo investigate both the gray matter (GM) and whiter matter (WM) alterations in a homogeneous cohort of early HIV-infected patients by combining voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS).Materials And MethodsTwenty-six HIV and 26 control subjects enrolled in this study with 3D T1 and diffusion-tensor imaging acquired on a 3.0T Siemens scanner. Group differences in regional GM were assessed using VBM analysis, while differences in fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and relative anisotropy (RD) of WM were evaluated using TBSS analysis. After that, interactions between GM changes and white matter alterations were investigated by using a correlation analysis.ResultsThe HIV-infected patients displayed decreased GM volume, mainly located in the bilateral frontal cortices, bilateral anterior cingulate cortex, and left supplementary motor area (P < 0.05, false discovery rate-corrected). Meanwhile, the patient group showed decreased FA in the genu of capsule callosum, body of capsule callosum, and bilateral anterior corona radiate (P < 0.05, family wise error [FEW]-corrected). Areas of increased MD, RD, and AD in HIV patients were more extensive and observed in most skeleton locations (P < 0.05, FEW-corrected). The interaction analysis in the patient group revealed that there were no significant correlations between GM changes and WM alterations (P > 0.05).ConclusionOur results indicate that structural brain alterations occurred early in HIV-infected patients. The current study may shed further light on the potential brain effects of HIV. J. Magn. Reson. Imaging 2016;43:1474-1483.© 2015 Wiley Periodicals, Inc.

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