• Amir Ashraf-Ganjouei, Farzaneh Rahmani, Aarabi Mohammad Hadi MH Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran., Hossein Sanjari Moghaddam, Mohammad-Reza Nazem-Zadeh, Esmaeil Davoodi-Bojd, and Hamid Soltanian-Zadeh.
• Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
• Neurol. Sci. 2019 Jun 1; 40 (6): 1209-1216.

BackgroundMedial temporal lobe epilepsy (mTLE) has been associated with widespread white mater (WM) alternations in addition to mesial temporal sclerosis (MTS). Herein, we aimed to investigate the correlation between disease duration and WM structural abnormalities in mTLE using diffusion MRI (DMRI) connectometry approach.MethodDMRI connectometry was conducted on 24 patients with mTLE. A multiple regression model was used to investigate white matter tracts with microstructural correlates to disease duration, controlling for age and sex. DMRI data were processed in the MNI space using q-space diffeomorphic reconstruction to obtain the spin distribution function (SDF). The SDF values were converted to quantitative anisotropy (QA) and used in further analyses.ResultsConnectometry analysis identified impaired white matter QA of the following fibers to be correlated with disease duration: bilateral retrosplenial cingulum, bilateral fornix, right inferior longitudinal fasciculus (ILF), and genu of corpus callosum (CC) (FDR = 0.009).ConclusionOur results were obtained from DMRI connectometry, which indicates the connectivity and the level of diffusion in nerve fibers rather just the direction of diffusion. Compared to previous studies investigating the correlation between duration of epilepsy and white matter integrity in mTLE patients, we detected broader and somewhat different associations in midline structures and component of limbic system. However, further studies with larger sample sizes are required to elucidate previous and current results.

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