• Enedino Hernández-Torres, Vanessa Wiggermann, Lindsay Machan, A Dessa Sadovnick, Li David K B DKB UBC MRI Research Centre, University of British Columbia, Vancouver, Canada. Department , Anthony Traboulsee, Simon Hametner, and Alexander Rauscher.
• UBC MRI Research Centre, University of British Columbia, Vancouver, Canada.
• J Magn Reson Imaging. 2019 Jul 1; 50 (1): 201-208.

BackgroundMagnetic resonance relaxometry studies in multiple sclerosis (MS) have suggested that iron accumulates within deep gray matter (DGM) structures early in the disease course. However, the commonly utilized mean R2* and magnetic susceptibility measures reflect regional iron concentration but not a structure's total iron content. Thus, tissue atrophy could impact mean R2* and magnetic susceptibility estimates.PurposeTo demonstrate that both average iron concentration and total iron content need to be reported in order to distinguish between atrophy-related and definite magnetic susceptibility changes.Study TypeObservational.PopulationThe study was performed on 30 healthy controls (HCs) and 39 people with definite MS.Field Strength/Sequence3T Philips Achieva using an 8-channel SENSE head coil. R2* data were acquired using a multiecho gradient echo sequence and diffusion tensor imaging data were acquired using an echo-planar sequence.AssessmentTotal iron content in DGM structures was assessed by calculating the sum of all R2* values within a region (denoted as R 2 m a s s * ) and compared to the mean R2* as a measure of iron concentration.Statistical TestSignificant group differences were investigated in a linear regression model. All DGM structures were assessed individually and the significance threshold was adjusted using the Bonferroni-Holm correction for multiple comparisons.ResultsThere was an increased mean DGM R2* in MS patients compared to HCs (significant in the pallidus, P = 0.0051). In contrast, R 2 m a s s * in patients was found to be lower in the thalamus and the caudate (P = 0.0011) compared to HCs, and similar between the two cohorts in the other DGM regions.Data ConclusionAn increase in mean R2* may not necessarily reflect increased iron accumulation. We propose R 2 m a s s * as an additional metric to account for the effects of tissue atrophy when assessing tissue content changes, such as iron deposition or loss.Level Of Evidence1 Technical Efficacy: Stage 1 J. Magn. Reson. Imaging 2019;50:201-208.© 2018 International Society for Magnetic Resonance in Medicine.

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