• Yanming Cao, Xunzhi Liu, and Haibo Xu.
• Department of Orthopaedics, the Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, P. R. China.
• Clin Lab. 2012 Jan 1; 58 (7-8): 845-50.

BackgroundThe goal was to find out the clinical significances of tartrate-resistant acid phosphatase isoform 5b (TRACP 5b), a biomarker of bone resorption, and bone alkaline phosphatase (BAP) and osteocalcin, two markers of bone formation, in evaluating the osteoporotic fracture risk in Chinese patients.MethodsThirty six Chinese osteoporotic fracture patients and 32 Chinese healthy subjects were included in the study. Bone mineral density (BMD) of lumbar spine and total body were determined by dual-energy X-ray absorptiometry in all subjects. Fasting blood samples were collected from all subjects and the serum concentrations of TRACP 5b, BAP, and osteocalcin were analyzed with enzyme-linked immunosorbent assay or immunoradiometric assay.ResultsWith lower BMD, the osteoporotic fracture patients had elevated levels of TRACP 5b and BAP, compared with the healthy controls. No difference in serum osteocalcin level was observed between the fracture patients and the control.ConclusionsElevated serum TRACP 5b and BAP, combined with or without increased osteocalcin, are valuable tools for the assessment of osteoporotic fracture risk in Chinese patients.

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