• Samir D Sharma, Roland Fischer, Bjoern P Schoennagel, Peter Nielsen, Hendrik Kooijman, Jin Yamamura, Gerhard Adam, Peter Bannas, Diego Hernando, and Scott B Reeder.
• Department of Radiology, University of Wisconsin, Madison, Wisconsin, USA.
• Magn Reson Med. 2017 Jul 1; 78 (1): 264-270.

PurposeWe aimed to determine the agreement between quantitative susceptibility mapping (QSM)-based biomagnetic liver susceptometry (BLS) and confounder-corrected R2* mapping with superconducting quantum interference device (SQUID)-based biomagnetic liver susceptometry in patients with liver iron overload.MethodsData were acquired from two healthy controls and 22 patients undergoing MRI and SQUID-BLS as part of routine monitoring for iron overload. Magnetic resonance imaging was performed on a 3T system using a three-dimensional multi-echo gradient-echo acquisition. Both magnetic susceptibility and R2* of the liver were estimated from this acquisition. Linear regression was used to compare estimates of QSM-BLS and R2* to SQUID-BLS.ResultsBoth QSM-BLS and confounder-corrected R2* were sensitive to the presence of iron in the liver. Linear regression between QSM-BLS and SQUID-BLS demonstrated the following relationship: QSM-BLS = (-0.22 ± 0.11) + (0.49 ± 0.05) · SQUID-BLS with r2  = 0.88. The coefficient of determination between liver R2* and SQUID-BLS was also r2  = 0.88.ConclusionWe determined a strong correlation between both QSM-BLS and confounder-corrected R2* to SQUID-BLS. This study demonstrates the feasibility of QSM-BLS and confounder-corrected R2* for assessing liver iron overload, particularly when SQUID systems are not accessible. Magn Reson Med 78:264-270, 2017. © 2016 International Society for Magnetic Resonance in Medicine.© 2016 International Society for Magnetic Resonance in Medicine.

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