• Marina Boccardi, Martina Bocchetta, Liana G Apostolova, Gregory Preboske, Nicolas Robitaille, Patrizio Pasqualetti, Louis D Collins, Simon Duchesne, Clifford R Jack, Giovanni B Frisoni, EADC-ADNI Working Group on The Harmonized Protocol for Hippocampal Volumetry, and Alzheimer's Disease Neuroimaging Initiative.
• LENITEM (Laboratory of Epidemiology, Neuroimaging and Telemedicine) IRCCS - S. Giovanni di Dio - Fatebenefratelli Brescia, Italy.
• J Neuroimaging. 2014 Sep 1;24(5):509-14.

Background And PurposeAn effort to define and validate a Harmonized Protocol for standard hippocampal segmentation is being carried out. We wished to estimate the effect of magnetic resonance image (MRI) spatial orientation on manual hippocampal segmentations to define optimal standard orientation of MRIs for hippocampal volumetry.MethodsThree expert tracers segmented twice the hippocampi of 10 ADNI subjects on MRI slices oriented perpendicular to the anterior-posterior commissure (AC-PC) line and the long hippocampal axes plane, following internationally harmonized landmarks. We computed intra and interrater reliability figures for total volumes and similarity coefficients.ResultsTotal volume reliability was similar for both orientations. Similarity coefficients were significantly higher for the AC-PC orientation (exact P = 0.002).DiscussionThese data show that AC-PC orientation is slightly more reliable for manual segmentations, possibly due to better visualization of the cerebrospinal fluid spaces separating hippocampal head and amygdala. A Delphi panel of experts has used these data to decide on the optimal orientation for a Harmonized Protocol for hippocampal segmentation.Copyright © 2013 by the American Society of Neuroimaging.

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