• Frank Dreher, Zoe D Draelos, Michael H Gold, Mitchel P Goldman, Sabrina G Fabi, and Mary L Puissegur Lupo.
• Neocutis, Inc., 3053 Fillmore Street, #140, San Francisco, CA 94123, USA. frank.dreher@neocutis.com
• J Cosmet Dermatol. 2013 Mar 1; 12 (1): 12-7.

BackgroundHyperpigmentation and solar damage remains a difficult problem to treat with topical agents.AimsTo evaluate a novel skin-lightening complex (SLC) comprising four actives targeting melanin formation at multiple levels, namely disodium glycerophosphate, L-leucine, phenylethyl resorcinol, and undecylenoyl phenylalanine, in an oil-in-water emulsion cream.Patients/MethodsSkin-lightening complex was evaluated in 80 female subjects of skin types I-III with at least moderate mottled hyperpigmentation. After a wash-out period of 1 month with a sunscreen, the subjects added a cream containing the SLC for 12 weeks twice daily to entire face and continued the sunscreen use.ResultsWhereas there was no significant change during the wash-out period, the primary endpoint mottled hyperpigmentation decreased by 32% after the 12-week treatment period with the SLC cream. Secondary endpoints such as severity and number of lentigines, skin tone, and skin brightness also improved. In all, 57% of the subjects showed at least a moderate response, 17% did not improve, and 3% got worse after the treatment.ConclusionsThe SLC cream was well tolerated, in particular when comparing with exfoliating or peeling agent containing skin-lightening products. When used with a daily sunscreen, this study confirms that the SLC represents an alternative to hydroquinone, retinoids, and many other skin-lightening actives.© 2013 Wiley Periodicals, Inc.

33 keywords...

hide…