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Med. Clin. North Am. · Nov 2002
ReviewBarrett's esophagus and esophageal adenocarcinoma: pathogenesis, diagnosis, and therapy.
- Stuart Jon Spechler.
- Division of Gastroenterology, Dallas Veterans Affairs Medical Center, University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA.
- Med. Clin. North Am. 2002 Nov 1; 86 (6): 1423-45, vii.
AbstractGastric juice that refluxes into the esophagus can injure esophageal squamous epithelium. When the injury heals through a metaplastic process in which an abnormal columnar epithelium replaces the injured squamous one, the resulting condition is called Barrett's esophagus. Gastroesophageal reflux disease and Barrett's esophagus are the most important risk factors for esophageal adenocarcinoma. This article examines such issues as the treatment, endoscopic surveillance, and chemoprevention of Barrett's esophagus. Also included are published guidelines and recommendations.
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