• Rasha Alshahawy, Nihal El Habachi, Eman Allam, Fredrik Jernerén, Helga Refsum, and Amany Elshorbagy.
• Department of Physiology, Faculty of Medicine, University of Kafr-Elshikh, Kafr-Elshikh, Egypt. Electronic address: rasha_alshahawy@med.kfs.edu.eg.
• Nutrition. 2021 Oct 1; 90: 111306.

ObjectiveThe aim of this study was to examine the time scale of plasma fatty acid changes during transition to an exclusively plant- and fish-based diet in healthy individuals and determine whether there are associated alterations in arachidonic acid (ARA)-derived inflammatory mediators, estimated stearoyl coenzyme A desaturase (SCD) activity, and blood pressure.MethodsIn pursuit of a religious fast, 36 adults abstained  from eating poultry, meat, dairy products, and eggs, while increasing fish intake for 6 wk. Participants were assessed 1 wk before (W0) and 1 (W1) and 6 (W6) weeks after the diet change.ResultsBy W6, fasting plasma long-chain ω-3 polyunsaturated fatty acids (ω-3 LC-PUFAs); docosahexaenoic (DHA) and eicosapentaenoic (EPA) had increased (+67% and +73%, respectively; P ≤ 0.001), with early rise of DHA (+22%), but not EPA at W1.The ω-3 index (sum of DHA and EPA as a percent of total fatty acids) increased from 2.1% to 3.4%. ARA decreased progressively (W1, -9%; W6, -16%; P < 0.001). ARA precursors γ-linolenic and dihomo-γ-linolenic acids also decreased, without changes in the ARA-derived mediators prostaglandin-E2 and leukotriene-B4. Myristic acid decreased at W1 (-37%) and W6 (-40%). There was no consistent change in SCD indices. At W6, systolic and diastolic blood pressure had declined by 8 and 5 mm Hg, respectively (P ≤ 0.013).ConclusionsShifting to a plant- and fish-based diet produces rapid and sustained increases in ω-3 LC-PUFAs and decreases the ω-6 PUFA ARA and its precursors, consistent with a cardio-protective profile. The rapid response suggests that these biomarkers may be useful for assessment of diet interventions.Copyright © 2021 Elsevier Inc. All rights reserved.

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