• Karin Amrein, Magdalena Hoffmann, Elisabeth Lobmeyr, and Gennaro Martucci.
• Division of Endocrinology and Diabetology.
• Curr Opin Crit Care. 2021 Aug 1; 27 (4): 378-384.

Purpose Of ReviewTo summarize the recent evidence on the role of vitamin D deficiency in critically ill patients and emerging data claiming a role of vitamin D in COVID-19.Recent FindingsVitamin D is a strong predictor for worse outcomes in critically ill patients, and as well in COVID-19. The vitamin D content in typical nutrition regimes is lower than what is recommended for the general population. Although its supplementation has been shown to reduce respiratory tract infections, asthma exacerbations and mortality risk in noncritically ill patients, its role in the acute setting is not yet clear. Several small intervention trials have shown interesting results in COVID-19, and larger studies are ongoing.SummaryAlthough research on this topic is still ongoing, it appears reasonable to recommend at least the standard vitamin dose for the healthy population (600--800 IU of native vitamin D3). Many questions remain on the actual role, the best metabolite, regime, and so forth. However, the role for vitamin D in bone health is clear. Elderly ICU survivors have a high risk for osteoporosis/fractures, so at least in this population, an optimal vitamin D status should be targeted.Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.

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