• Lung Cancer · Sep 2016

    Case Reports

    Drug-induced myocarditis after nivolumab treatment in a patient with PDL1- negative squamous cell carcinoma of the lung.

    • H Semper, F Muehlberg, J Schulz-Menger, M Allewelt, and C Grohé.
    • ELK Thorax Center, Lindenberger Weg 27, 13125 Berlin, Germany.
    • Lung Cancer. 2016 Sep 1; 99: 117-9.

    AbstractImmunotherapy such as nivolumab is a new promising therapeutic option for advanced stage non small cell lung cancer (NSCLC). Due to the interference with the immune system previously unknown side effects are observed both in clinical studies and experience. Autoimmune phenomena effecting skin, gastrointestinal tract, endocrine glands, kidney and lung have been described. Up to now there is only limited information regarding potential cardiac side effects. We present a case of symptomatic drug induced myocarditis after nine cycles of nivolumab in a patient with efficient anticancer response.Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.

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