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J. Clin. Endocrinol. Metab. · Sep 1977
Potentiation of insulin action: a probable mechanism for the anti-diabetic action of sulfonylurea drugs.
- H E Lebovitz, M N Feinglos, H K Bucholtz, and F L Lebovitz.
- J. Clin. Endocrinol. Metab. 1977 Sep 1; 45 (3): 601-4.
AbstractInsulin action was assessed by measuring insulin-mediated glucose disposal (KI) in 13 non-ketotic diabetic patients both before treatment and after normalization of plasma glucose by diet (5 patients) or sulfonylurea (glipizide) therapy (8 patients). While the KI of the diet-treated group was unchanged by therapy, that of the glipizide-treated group was significantly increased. The data show that chronic glipizide therapy is associated with a potentiation of insulin action, which may account for the major anti-diabetic effect of this drug.
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