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- Chirag Vaidya, Warren Ho, and Benjamin J Freda.
- Tufts University School of Medicine, Renal Division, Baystate Medical Center, MA, USA.
- Cleve Clin J Med. 2010 Oct 1; 77 (10): 715-26.
AbstractHyponatremia, in its most severe form, requires urgent infusion of hypertonic saline to correct cerebral edema. However, overly rapid correction of chronic hyponatremia can cause osmotic demyelination syndrome. The authors review the treatment of hyponatremia in order to provide clinicians with a sound approach in a variety of settings in which severity, symptoms, and underlying disease states influence therapy. Also discussed is the current role of vasopressin antagonists in treatment.
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