• Saudi J Kidney Dis Transpl · Jul 2019

    Case Reports

    Cyclophosphamide-induced melanonychia in a patient with steroid dependent nephrotic syndrome: A rare presentation.

    • Sudhir Mehta, Vikas Makkar, P M Soha, Suman Sethi, and Simran Kaur.
    • Department of Nephrology, Dayanand Medical College and Hospital, Ludhiana, Punjab, India.
    • Saudi J Kidney Dis Transpl. 2019 Jul 1; 30 (4): 978-981.

    AbstractMelanonychia is described as a brown to black pigmentation of nail, due to stimulation and hyperplasia of nail matrix. Various systemic disorders, trauma, inflammatory disorders, fungal infections, drugs, benign melanocytic hyperplasia, etc., are responsible for this condition, and most of them are benign. A number of chemotherapeutic agents can cause melanonychia. Cases of cyclophosphamide-induced melanonychia are not frequent. We report a 38-year-old female, a known case of steroid dependent nephrotic syndrome, who developed melanonychia on starting treatment with cyclophosphamide. It is a benign condition, which resolves on discontinuation of the drug.

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