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Mayo Clinic proceedings · Feb 2008
ReviewTrastuzumab-induced cardiotoxicity: heart failure at the crossroads.
- Partho P Sengupta, Donald W Northfelt, Federico Gentile, Jose L Zamorano, and Bijoy K Khandheria.
- Division of Cardiovascular Diseases, Mayo Clinic, 13400 E Shea Blvd, Scottsdale, AZ 85259, USA.
- Mayo Clin. Proc. 2008 Feb 1; 83 (2): 197-203.
AbstractTrastuzumab, a drug targeting human epidermal growth factor receptor 2, improves survival rate in women with metastatic breast cancer. Symptomatic heart failure, a serious adverse effect of trastuzumab, occurs in 1% to 4% of patients treated with the antibody, whereas left ventricular ejection fraction declines substantially in 10% of patients. The prevalence of cardiotoxic effects of trastuzumab appears to increase with exposure to anthracyclines. Serial assessment of left ventricular function with 2-dimensional echocardiography or radionuclide ventriculography is the most practical means of monitoring cardiotoxicity. Patients who develop cardiotoxicity while receiving trastuzumab therapy generally improve once use of the agent is discontinued.
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