• NMR in biomedicine · Nov 2010

    High-sensitivity cerebral perfusion mapping in mice by kbGRASE-FAIR at 9.4 T.

    • Bingwen Zheng, Philip Teck Hock Lee, and Xavier Golay.
    • Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Biopolis, Singapore. zheng_bingwen@sbic.a-star.edu.sg
    • NMR Biomed. 2010 Nov 1; 23 (9): 1061-70.

    AbstractThe combination of flow-sensitive alternating inversion recovery (FAIR) and single-shot k-space-banded gradient- and spin-echo (kbGRASE) is proposed here to measure perfusion in the mouse brain with high sensitivity and stability. Signal-to-noise ratio (SNR) analysis showed that kbGRASE-FAIR boosts image and temporal SNRs by 2.01 ± 0.08 and 2.50 ± 0.07 times, respectively, when compared with standard single-shot echo planar imaging (EPI)-FAIR implemented in our experimental systems, although the practically achievable spatial resolution was slightly reduced. The effects of varying physiological parameters on the precision and reproducibility of cerebral blood flow (CBF) measurements were studied following changes in anesthesia regime, capnia and body temperature. The functional MRI time courses with kbGRASE-FAIR showed a more stable response to 5% CO(2) than did those with EPI-FAIR. The results establish kbGRASE-FAIR as a practical and robust protocol for quantitative CBF measurements in mice at 9.4 T.

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