• Alexey Surov, Leonard Leifels, Hans Jonas Meyer, Karsten Winter, Osama Sabri, and Sandra Purz.
• Department of Diagnostic and Interventional Radiology, University Hospital of Leipzig, Leipzig, Germany Alexey.Surov@medizin.uni-leipzig.de.
• Anticancer Res. 2018 Mar 1; 38 (3): 1637-1642.

AimTo analyze associations between parameters of positron-emission tomography (PET) and histogram analysis values of dynamic contrast-enhanced (DCE) imaging in patients with head and neck squamous cell carcinoma (HNSCC).Patients And MethodsOverall, 28 patients with primary HNSCC of different localizations were involved. 18F-FDG-PET/CT and DCE MR imaging were performed for all patients. Histogram analysis parameters of DCE MRI were calculated. Spearman's correlation coefficient was used to analyze the associations between investigated parameters.ResultsIn the overall cohort, SUVmax correlated with Kep P10 (ρ=0.43, p=0.027), Kep P25 (0.40, p=0.035), and had a tendency to correlate with median Kep (ρ=0.33, p=0.098). TLG tended to correlate with Kep P25 (0.33, p=0.09) and P10 Ktrans (ρ=0.35, p=0.07). In G1/2 tumors, SUVmax correlated with Kep P10 (ρ=0.645, p=0.032), and tended to correlate with Ktrans mean (ρ=0.54, p=0.089), Ktrans min (ρ=0.58, p=0.06), Ktrans P10 (ρ=0.56, p=0.07), Ktrans P25 (ρ=0.59, p=0.056), and Ktrans median (ρ=0.054, p=0.089), as well with Kep min (ρ=0.56, p=0.07). SUVmean tended to correlate with Kep kurtosis (ρ=0.56, p=0.07). In G3 tumors, no tendencies or statistically significant correlations between the PET and DCE MRI parameters were identified.ConclusionTumor metabolism and perfusion show complex associations in HNSCC. These associations depend on tumor grading.Copyright© 2018, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

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