• Nils Dennhardt, Christiane Beck, Dirk Huber, Katja Nickel, Björn Sander, Lars-Henrik Witt, Dietmar Boethig, and Robert Sümpelmann.
• From the Clinic for Anaesthesiology and Intensive Care Medicine (ND, CB, DH, KN, BS, LHW, RS), and Clinic for Cardiac, Thoracic, Transplant and Vascular Surgery, Hanover Medical School, Hanover, Germany (DB).
• Eur J Anaesthesiol. 2015 Dec 1; 32 (12): 857-61.

BackgroundIn contrast to preoperative fasting guidelines in paediatric anaesthesia, actual fasting times are often too long.ObjectiveThe objective of this study was to evaluate the effect of preoperative fasting on glucose concentration, ketone bodies and acid-base balance in children.DesignA prospective, noninterventional, clinical observational study.SettingA single-centre trial, study period from June 2014 to November 2014.PatientsOne hundred children aged 0 to 36 months scheduled for elective paediatric surgery.Main Outcome MeasuresPatient demographics, fasting times, haemodynamic data, glucose and ketone body concentrations, and acid-base parameters after induction of anaesthesia were documented using a standardised case report form.ResultsMean fasting period was 7.8 ± 4.5 (3.5 to 20) h, and deviation from guideline (ΔGL) was 3.3 ± 3.2 (-2 to 14) h. Linear regression showed a significant correlation between fasting times and ketone bodies, anion gap, base excess, osmolality as well as bicarbonate (for each, P < 0.05), but not glucose or lactate. In children with ΔGL more than 2 h (54%), ketone bodies, osmolality and anion gap were significantly higher and base excess significantly lower than children with ΔGL less than 2 h (for each, P < 0.05).ConclusionAfter prolonged preoperative fasting, children younger than 36 months can present with ketoacidosis and (low) normal blood glucose concentrations. Actual fasting times should be optimised according to existing guidelines. In small infants, deviations from fasting guidelines should be as short as possible and not longer than 2 h.

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