• Basic Clin. Pharmacol. Toxicol. · Aug 2009

    Effects of intrathecal injection of nicotine on the analgesic effects of isoflurane in a model of inflammatory pain.

    • Wei Cheng, Qin Yin, Yin-Ming Zeng, Shu Wang, Hong-Sheng Chen, and Tao Feng.
    • Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical College, Xuzhou 221002, China.
    • Basic Clin. Pharmacol. Toxicol. 2009 Aug 1; 105 (2): 120-5.

    AbstractThe present study was designed to investigate the role of spinal neuronal nicotinic acetylcholine receptors in the analgesic effects of isoflurane. After having established the mice model of analgesia by intraperitoneally injecting (i.p.) appropriate doses of isoflurane, nicotine, a neuronal nicotinic acetylcholine receptor agonist was intrathecally injected. The effects of isoflurane and nicotine on paw licking times and formalin-induced c-fos expression in the spinal cord dorsal horn were examined. Our correlative studies have shown that isoflurane can decrease the paw licking times and simultaneously suppress c-fos expression after injection of formalin in the mice. Nicotine can partially antagonize the effects induced by isoflurane above. Spinal neuronal nicotinic acetylcholine receptors may be important targets for the analgesic effects of isoflurane in formalin pain.

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