Clinical features, isolation, and complete genome sequence of

J. Med. Virol. · Oct 2020

Case Reports

Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam.

In January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. ⋯ The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.

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- Lan T Phan, Thuong V Nguyen, Loan K T Huynh, Manh H Dao, Tho A N Vo, Nhung H P Vu, Hang T T Pham, Hieu T Nguyen, Thuc T Nguyen, Hung Q Le, Thinh V Nguyen, Quan H Nguyen, Thao P Huynh, Sang N Nguyen, Anh H Nguyen, Ngoc T Nguyen, Thao N T Nguyen, Long T Nguyen, Quang C Luong, Thang M Cao, and Quang D Pham.
- Directorial Board, Pasteur Institute of Ho Chi Minh City, Ho Chi Minh City, Vietnam.
- J. Med. Virol. 2020 Oct 1; 92 (10): 2209-2215.
AbstractIn January 2020, we identified two severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-infected patients in a familial cluster with one person coming from Wuhan, China. The complete genome sequences of two SARS-CoV-2 strains isolated from these patients were identical and 99.98% similar to strains isolated in Wuhan. This is genetically suggestive of human-to-human transmission of SARS-CoV-2 and indicates Wuhan as the most plausible origin of the early outbreak in Vietnam. The younger patient had a mild upper respiratory illness and a brief viral shedding, whereas the elderly with multi-morbidity had pneumonia, prolonged viral shedding, and residual lung damage. The evidence of nonsynonymous substitutions in the ORF1ab region of the viral sequence warrants further studies.© 2020 Wiley Periodicals LLC.

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Clinical features, isolation, and complete genome sequence of severe acute respiratory syndrome coronavirus 2 from the first two patients in Vietnam.

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