• J. Med. Chem. · Jul 1979

    2-Acetylpyridine thiosemicarbazones. 1. A new class of potential antimalarial agents.

    • D L Klayman, J F Bartosevich, T S Griffin, C J Mason, and J P Scovill.
    • J. Med. Chem. 1979 Jul 1; 22 (7): 855-62.

    AbstractBased on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.

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