-
- D L Klayman, J F Bartosevich, T S Griffin, C J Mason, and J P Scovill.
- J. Med. Chem. 1979 Jul 1; 22 (7): 855-62.
AbstractBased on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against Plasmodium berghei in mice. Screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at N4 of the thiosemicarbazone moiety also contribute to antimalarial activity.
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